NAD MAKES HISTORY
Nicotinamide Adenine Dinucleotide (NAD) is a coenzyme that is extensively researched because of its central role in many biological functions. In recent years, scientific studies and clinical trials have paved the way for a single molecule to become one of the most important discovery in medicine
STUDIES INVOLVING NAD ARE SKYROCKETING. MORE THAN 50 000 RELATED PUBLICATIONS ARE AVAILABLE ON PUBMED, COVERING MAJOR DESEASES AND METABOLIC DISORDERS.
NAD IS A UNIVERSAL KEY COMMUNICATION MOLECULE
NAD is crucial for enzymatic reactions in every living cells. From the simplest bacteria to humans, life could not exist without NAD. That is why NAD is one of the most researched molecules in biology and medicine.
NAD IS CRUCIAL FOR YOUR CELLS
NAD is at the center of many vital functions such as converting the energy from the food into the energy the body needs (ATP), DNA Repair (PARP1), SIRTUINs activation, telomere maintenance, neurotransmitter function, extracellular signaling and more.
NMN AND NAD, THE INTIMATE RELATIONSHIPS
NMN, AN OUTSTANDING PRECURSOR
NMN is a precursor, which means a molecular building blocks of NAD: when in the cells NMN is rapidly used to form NAD. NMN is both available in the bloodstream, and, once inside a cell, able to bypass the rate‐limiting enzyme in NAD production, which makes it the perfect NAD precursor.
THE NMN TRANSPORTER
NMN is directly transported from the bloodstream into the cells by a special protein called sic98c. In vivo NMN is absorbed from the gut into blood circulation within 2–3 min and transported into tissues within 10–30 min. NMN is then immediately utilized for NAD+ biosynthesis, significantly increasing NAD+ content in tissues over 60 min. In short, NMN is easily uptaken in the cells throughout the body, which is not the case of the other precursors, such as NR (commercially named NIAGEN), Nicotinamide and Niacin.
QUERCETIN, A POWERFUL SENOLYTIC
A senolytic is a molecule able to selectively induce death of senescent cells and consequently improve lifespan in humans. Senescent cells accumulate in many tissues with aging and at sites of pathology in multiple chronic diseases. Quercetin is a polyphenol found in many fruits, vegetables, leaves, and grains, known to improve metabolic health by activating longevity genes. Studies and clinical trials with various doses have have been proven to improve physical functions and increase lifespan.
HUMAN STUDIES ABOUT NMN & QUERCETIN
- 2016 Keio University Study – UMIN000021309 Phase 1, 12 subjects
- 2017 Keio University Study – UMIN000030609 Phase 2, 8 weeks, 30 subjects
- 2017 Hiroshima University Study – UMIN000025739 24 weeks, 20 subjects, 100 & 200mg
- 2017 University of Washington Study 8 weeks, 50 subjects
- 2017 Sinclair Metrobio study – Phase 1
- 2018 Sinclair Metrobio study – Phase 2
- 2011 Modulation of Cerebral Blood Flow Using Quercetin, a Nutritional Supplement
- 2013 Effects of Quercetin on Blood Sugar and Blood Vessel Function in Type 2 Diabetes.
- 2013 Effect of Quercetin Supplements on Healthy Males: a Four-Week Randomized Cross-Over Trial
- 2012 Prostate Cancer Prevention Trial With Quercetin and Genistein (QUERGEN)
- 2016 Beneficial Effects of Quercetin in Chronic Obstructive Pulmonary Disease (COPD) (Quercetin)